Feb 12, 2014
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Wall. ex G. Don.

Family ► Ericaceae.

Habitat ► The Himalayas from Kumaon to Bhutan, extending to Assam.

English ► Giantblood Rhododendron.

Folk ► Chimal (Nepal), Kurbak, Guraans.

Action ► Respiratory depressant, emetic, toxic.

The leaves and flowers gave an- dromedotoxin which resembles tertiary amine veratrum alkaloids, particularly protoveratrine, in pharmacological action. Intravenous administration of andromedotoxin to dogs resulted in 20-40% reduction in blood pressure. It also closely resembles protoveratrine in its stimulating effect on the barostatic-pressor-reflex- mechanism, respiratory effects and emetic action. It produces reflex va- sodepressor responses in intact animals; in debuffered dogs, it produced vasopressor responses. It also produced, both direct and indirect, positive ionotropic effects, the latter being more pronounced.

The leaves contain ursolic acid, alpha-amyrin, epi-friedelinol, cam- panulin and hyperoside. Chloroform extract of the leaves and shoots showed a depressant action. The honey from flowers is poisonous; contains an- dromedotoxin.

Article Categories:
Indian Medicinal Plants

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