A hard swelling, or GRANULOMA, characteristic of tertiary SYPHILIS. It normally develops in the skin or subcutaneous tissue, mucous membranes or submucosa, and the long bones. Although often painless, it may produce marked symptoms by interfering with the brain or other internal organs in which it may be located. Treatment with penicillin (or tetracycline if the patient is allergic) usually ensures a rapid disappearance of the gumma.
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