A condition in which the ﬁngers or toes, or even larger portions of the limbs, become purple and bloated in appearance, and very painful. In people suﬀering from the condition – which is not a common one – the attacks come and go, being worse in summer (unlike chilblains), and worse on exertion or when the aﬀected parts are warmed or allowed to hang down. The condition may appear without apparent cause, but is often associated with vascular diseases, such as HYPERTENSION and POLYCYTHAEMIA VERA. It aso occurs in association with certain diseases of the central nervous system, and in cases of metallic poisoning
(e.g. arsenic, mercury and thallium). Treatment is unsatisfactory but aspirin provides sympomatic relief.