Disulﬁram is used as an adjunct in the treatment of alcoholism. It is relatively non-toxic by itself, but when taken in conjunction with alcohol it produces most unpleasant eﬀects: for example, ﬂushing of the face, palpitations, a sense of oppression and distress, and ultimately sickness and vomiting. The rationale of treatment therefore is to give the alcoholic subject a course of disulﬁram and then demonstrate, by letting him or her take some alcoholic liquor, how unpleasant are the eﬀects. If the patient is co-operative, the treatment may be eﬀective, but there is some risk so it must be given under skilled medical supervision.
Article Categories:Medical Dictionary