Didanosine (ddI, DDI) is a nucleoside reverse transcriptase inhibitor used to treat progressive or advanced HIV infection (see AIDS/HIV). Preferably it should be given in combination with other antiretroviral drugs. This drug has a range of potentially serious side-eﬀects such as pancreatitis (see PANCREAS, DISEASES OF), peripheral NEUROPATHY, DIABETES MELLITUS and liver failure. Its use requires monitoring and patients taking it should receive counselling.
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