An antibiotic used in the treatment of serious infections. It is active against gram-positive cocci, including penicillin-resistant staphylococci (see STAPHYLOCOCCUS) and also many anaerobes (see ANAEROBE), especially Bacteroides fragilis. It is recommended for staphylococcal bone and joint infections such as OSTEOMYELITIS and intra-abdominal sepsis, as well as ENDOCARDITIS prophylaxis. Clindamycin has only limited use because of its adverse eﬀects; patients should discontinue immediately if diarrhoea or colitis develops.
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