One of the antimuscarinic (see ANTIMUSCARINE) group of drugs used to treat PARKINSONISM. Acting by correcting the relative central cholinergic excess resulting from DOPAMINE deﬁciency, the drug has a moderate eﬀect, reducing tremor and rigidity but with little action on BRADYKINESIA. It has a synergistic (see SYNERGIST) eﬀect when used with LEVODOPA and is useful in reducing SIALORRHOEA. Valuable in treating cases of Parkinsonian side-eﬀects occurring with neuroleptic drugs. Tardive DYSKINESIA is not improved and may be made worse.
There are few signiﬁcant diﬀerences between the various antimuscarinic drugs available, but some patients may tolerate one drug better than another or ﬁnd that they need to adjust their drug regimen in relation to food.