Apr 6, 2014
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One of the antimuscarinic (see ANTIMUSCARINE) group of drugs used to treat PARKINSONISM. Acting by correcting the relative central cholinergic excess resulting from DOPAMINE deficiency, the drug has a moderate effect, reducing tremor and rigidity but with little action on BRADYKINESIA. It has a synergistic (see SYNERGIST) effect when used with LEVODOPA and is useful in reducing SIALORRHOEA. Valuable in treating cases of Parkinsonian side-effects occurring with neuroleptic drugs. Tardive DYSKINESIA is not improved and may be made worse.

There are few significant differences between the various antimuscarinic drugs available, but some patients may tolerate one drug better than another or find that they need to adjust their drug regimen in relation to food.

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Medical Dictionary

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