These are antimuscarinic drugs (see ANTIMUSCARINE) which have the property of relaxing smooth muscle. Along with other antimuscarinic drugs, antispasmodics may be helpful supportive treatment for patients with non-ulcer DYSPEPSIA, IRRITABLE BOWEL SYNDROME (IBS) and DIVERTICULAR DISEASE. Examples of antispasmodic drugs are ATROPINE sulphate, dicyclomine bromide and propantheline (a synthetic antimuscarinic drug used as a treatment adjunct in gastrointestinal disorders and also for controlling urinary frequency), bromide, alverine, mebervine and peppermint oil. With the arrival of more powerful and speciﬁc antisecretory drugs, such as the histamine H2-receptor antagonists – examples are CIMETIDINE and RANITIDINE – the use of antispasmodics has declined.
Article Categories:Medical Dictionary