A group of antibiotics usually reserved for use in patients with severe infections. They are eﬀective against a wide range of BACTERIA including some gram-positive and many gram-negative organisms (see GRAM’S STAIN). Aminoglycosides must be used cautiously because they can damage the inner ear – thus aﬀecting hearing – and the kidneys. Examples of this group are AMIKACIN and GENTAMICIN (eﬀective against Pseudomonas aeuriginosa), NEOMYCIN (used only for topical administration for skin infections), and STREPTOMYCIN (eﬀective in combination with other drugs against Mycobacterium tuberculosis).
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